The Tamesis
Where there’s a will, there’s a way; when it comes to bright, bouncy, blemish-free skin, there’s almost nothing I won’t try – including PDRN. PDRN, short for its formal name, polydeoxyribonucleotide, is a compound traditionally derived from salmon DNA (most commonly salmon sperm). Numerous preclinical and clinical studies have demonstrated the ingredient’s anti-inflammatory and wound-healing properties, making it a popular addition to in-office skin treatments and, more recently, for topical use as a serum or cream. However, not all PDRN sera are derived from salmon. The ingredient is increasingly appearing in plant-based and vegan forms, whether for ethical reasons or simply for those who don’t like salmon sperm on their face, which is… fair enough.
Apparently, I’m not the only one willing to give it a try. According to Spate, an artificial intelligence-driven trend prediction service, PDRN’s average monthly Google searches are 1.6K, and TikTok’s average weekly views are 1.4 million. Many of the most popular PDRN formulas on the market come from Korea, and one of the most popular formulas is actually a personal favorite – Medicube PDRN Pink Peptide Serum.
You may already know Medicube is known for its viral Booster Pro device, beloved by A-listers like Kendall Jenner and Hailey Bieber, but the brand’s PDRN serum deserves just as much hype for its ability to fade dark spots and improve elasticity. Esthetician Emma Jin calls it “a really good hydrating and glowing serum.” She added that when used topically, PDRN is thought to help support skin repair and soothe the complexion, although its effects are intentionally subtle. Medicube creative director and celebrity makeup artist Sir John notes that the formula is safe for all skin types. “[Our] The entire PDRN range is truly balanced,” he says. “Whether your skin is dry, combination or very oily, it helps balance skin softness without weighing it down. “
Medicube PDRN Pink Peptide Serum
- Why we love it: This peptide serum is easy to add to any routine and is suitable for all skin types, including sensitive skin. The dropper allows for controlled use and its size makes it suitable for travel without triggering TSA. While this formula is vegan, it provides the same skin-supporting benefits as PDRN, along with a blend of niacinamide, adenosine, and peptides to help retain moisture, support uneven skin tone, and improve overall skin texture.
- Main ingredients: Rose PDRN, 5-peptide complex (acetyl hexapeptide-8, copper tripeptide-1, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4), nicotinamide, adenosine
- type: Light essence
- size: 30ml
About Medicube PDRN Pink Peptide Serum
While there are numerous PDRN products on the market, Medicube’s formula stands out for its Rose PDRN Complex (a blend of Damask rose extract and sodium DNA). Together, they help support the skin’s natural barrier, promote repair, and promote overall skin health. But vegan PDRN isn’t the only big hit here. The serum also contains a five-peptide complex to help firm skin, support collagen and soften fine lines, niacinamide to brighten uneven skin tone, and adenosine to smooth and strengthen overall skin structure. It’s also backed by clinical testing—according to the brand, users saw improvements in hyperpigmented areas, skin radiance, and texture in just two weeks, and that’s exactly what happened when I noticed the results myself.
Sir John added that serums can also improve the effect of makeup on the skin. “What’s special about [this] “What’s most important is how seamlessly it strengthens the skin’s moisture barrier,” he says. When the barrier is healthy, foundation applies better, lasts longer, looks smoother, and overall looks better. “You’ll get improved texture, longevity and finish.”
My experience with Medicube PDRN Pink Peptide Serum
I’m obsessed with Korean beauty for two reasons: I can’t stop talking about my trip to Seoul, and Korean formulas are often lightweight, gentle, and perfect for my sensitive skin. This pink peptide serum ticks all the boxes and absorbs quickly so I can get through my daily routine without interruption, which is ideal considering my general lack of patience. While I’m not morally opposed to putting salmon PDRN on my face, it’s nice to know that the formula is vegan and no fish were harmed in the process.
