7 Best Glutathione Supplements, According to Experts

Stress is considered a silent killer, but more specifically, oxidative stress in our cells has been linked to disease, decline, and health problems. The good news is that the best glutathione supplements can help. “Think of glutathione as your body’s natural protector,” explains Nayan Patel, MD, an expert in advanced biochemistry and anti-aging science and founder of wellness brand Auro. “It protects against daily stress, restores other antioxidants like vitamins C and E, and supports the body’s built-in detoxification pathways, starting with the liver, to help maintain balance at the cellular level.”

Glutathione is a highly specialized tripeptide and the most powerful antioxidant in the body. “Glutathione is unique in that it works within cells, and most oxidative stress actually occurs within cells,” says board-certified family medicine physician Heraa Chaudhry, MD. “Many antioxidants circulate in the blood, but glutathione works within cells to help neutralize free radicals at the source.”

fashion magazine Favorite glutathione supplements:

Best for antioxidant support

Cymbiotika Liposomal Glutathione

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Our bodies naturally produce glutathione and can maintain optimal levels through dietary and lifestyle factors. “Sulfur-rich foods like broccoli, Brussels sprouts, garlic and onions, along with adequate protein, regular exercise and quality sleep, are the foundation for adequate glutathione levels,” says Dr. Chowdhury. However, nearly every aspect of modern life can cause our glutathione levels to drop. “Over time, aging, chronic stress, environmental exposures, poor sleep quality and illness can all cause levels to decline,” says Dr. Patel. “Since oxidative stress is implicated in nearly every known disease process, glutathione is the body’s primary natural protector, helping to maintain balance at the cellular level.”

If you’re interested in this amazing antioxidant, we asked top experts to weigh in on the latest innovations, ingredients to prioritize, and how to evaluate the best glutathione supplements on the market.

Best Glutathione Supplement Overall:Pure capsule liposomal glutathione

• Why we love it: One of the reasons many professionals love Pure Encapsulations is its quality, transparency and effectiveness. This formula specifically provides liposomal delivery (125 mg of phospholipid complex) to prevent degradation during digestion. “When looking for effective glutathione supplements, clarity of formula, clear dosing, and a delivery system designed to improve intracellular absorption are all important,” says Dr. Patel. “Glutathione is sensitive to degradation, so look for a formula that focuses on stability and oxidative protection.” It also includes a clinically studied form of glutathione called Setria L-Glutathione, which is highly regarded for its purity, quality, and powerful effects. Pure Encapsulations also takes transparency a step further: While they list their proprietary Glutathione Complex, BioGrude, on the ingredients label, they break down exactly what’s in it—250 mg of Setria L-Glutathione and 125 mg of Phospholipid Complex—for complete clarity.
• Main ingredients: Setria Glutathione, Phospholipid Complex
• dose: 1 softgel
• form: Soft capsule
• size: 30 softgels

Best Glutathione Supplements for Antioxidant Support: Cymbiotika Liposomal Glutathione

• Why we love it: One daily gel pack provides a dose of citrus-vanilla flavored reduced glutathione, making it very convenient (and enjoyable) to take on a regular basis. It’s perfect for busy days, whether you’re on the go or stowed away in your travel bag. “Maximizing the benefits of glutathione depends on thoughtful formulation, consistency, and combining supplementation with supportive lifestyle habits such as proper nutrition, hydration, and restorative sleep,” says Dr. Chaudhry. This squeezable gel is made with other powerful antioxidants (CoQ10 and PQQ) as well as vitamin B12 for extra cellular support for a comprehensive approach.
• Main ingredients: Reduced glutathione, PQQ, vitamin B12
• dose: 1 pack
• form: gel
• size: 26 pack

Best Reduced Glutathione Supplements: BodyBio Liposomal Glutathione

• Why we love it: Glutathione exists in two different states within cells: oxidized state (GSSG) and reduced state (GSH). “Glutathione is an active antioxidant necessary to neutralize free radicals and protect the body from a range of toxins,” says Dr. Patel. Oxidized glutathione (GSSG) is essentially the inactive form of GSH produced when it neutralizes toxins. Studies have shown that oral glutathione supplements can effectively increase glutathione reserve levels in the body, thereby affecting immune function and oxidative stress levels. Third-party tested and manufactured in a cGMP-certified facility, the capsules not only contain reduced glutathione for optimal efficacy, but also come in liposomal form to ensure you’re actually getting the benefits of taking it.
• Main ingredients: Reduced glutathione, sunflower-derived phospholipids
• dose: 1 capsule
• form: capsule
• size: 60 capsules

Best Liposomal Glutathione Supplements: Codeage Liposomal Glutathione

• Why we love it: Glutathione encapsulated in liposomes (lipids that protect against stomach acid) helps it move more efficiently through the body to reach the intestine intact, helping to enhance absorption and bioavailability. “Due to its fat-based delivery system, liposomal glutathione may provide higher bioavailability than standard capsules,” Dr. Chaudhry said. Using a liposomal phospholipid complex derived from non-GMO sunflowers, this capsule delivers 500 mg of highly potent, clinically tested Setria L-Glutathione in a capsule powder pill form. It’s vegan, non-GMO, dairy-free, soy-free and gluten-free, making it a top choice for people with a variety of dietary restrictions.
• Main ingredients: Setaria L-Glutathione
• dose: 2 capsules
• form: capsule
• size: 60 capsules

The Best Glutathione Supplements with Milk Thistle: NOW Foods Glutathione

• Why we love it: Not only is this glutathione supplement affordable, available at your local health store, and made with high-quality ingredients, it’s also made with milk thistle extract to boost your glutathione levels. Some studies show that silymarin, the active ingredient in milk thistle seeds, can naturally increase glutathione levels by 35-50% by protecting liver cells and supporting their function. “Maintaining healthy glutathione levels contributes to the body’s ability to maintain optimal cell function, especially in high-demand systems such as the liver and nervous system,” explains Dr. Patel.
• Main ingredients: Glutathione, Milk Thistle Extract, Alpha-Lipoic Acid
• dose: 1 capsule
• form: capsule
• size: 30 capsules

Best Liquid Glutathione Supplements: Quicksilver Scientific Liposomal Glutathione

• Why we love it: Those who prefer to take their supplements in liquid form to avoid swallowing pills will love that it comes in two refreshing flavors – Lemon Mint and Cocoa Mint. There are several different delivery systems for glutathione, but according to Dr. Chaudhry, “Liposome formulations are designed to increase stability and bioavailability.” The liquid encapsulates the benefits of glutathione in tiny nanoliposomes less than 100 nanometers in size, which the brand says are more easily absorbed by the body. “Oral glutathione must be digested and its effects may vary, making delivery methods an increasingly important part of the longevity conversation,” Dr. Patel said. The daily dose is given as two pumps through the mouth, then holding the liquid in the mouth for 30-90 seconds before swallowing. Some research suggests that by using this sublingual method, it may help absorb nutrients faster through mucosal tissue and bypass digestion.
• Main ingredients: Opitac Glutathione, Phosphatidylcholine
• dose: 1 mL (2 pumps)
• form: liquid
• size: 1.7 ounces

Best Low-Dose Glutathione Supplements: Renue by Science Liposomal Glutathione

• Why we love it: Regularity is important when supplementing with glutathione, and one of the liposomal vegetarian capsules offers a low dose of 130 mg, perfect for beginners to help boost glutathione levels. Most clinical studies show benefits from consuming 250-500 mg of glutathione per day. Dr. Patel recommends starting with a low dose and working your way up if you’re new to glutathione. “Everyone’s baseline oxidative stress and detoxification capacity is different, so starting conservatively allows the body to adjust,” he says. “Consistency is more important than a high dose at the beginning.”
• Main ingredients: Glutathione, Sunflower Lecithin
• dose: 1 capsule
• form: capsule
• size: 90 capsules