11 Best Growth Factor Serums to Fighting Aging Without Irritation

When it comes to anti-aging skin care formulas, growth factor serums may be the most mysterious of them all. These rejuvenating formulas are praised for improving skin hydration and elasticity, smoothing skin texture, fading hyperpigmentation, and even tightening sagging, aging skin, so it’s no wonder they’re a best-seller, but what exactly? yes Growth factors?

Growth factors are natural proteins produced by the body’s cells and are essential for healthy skin. “They act as signaling molecules that communicate with skin cells, stimulating collagen production, promoting cell turnover, promoting wound healing, and improving overall skin tone and texture,” explains Eunice Park, MD, a double board-certified facial plastic and reconstructive surgeon.

fashion magazine Favorite Growth Factor Serum

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Unfortunately, as we age, our natural production of growth factors declines, says board-certified internist and longevity expert Amanda Kahn, MD. “As we age, this can cause the skin to become thinner, wrinkly, less firm, less elastic, and sagging,” she explains. By replenishing the skin’s stores of these powerful proteins, a high-quality growth factor serum can help skin function optimally, allowing skin cells to respond and repair to their full potential, says board-certified facial plastic surgeon Sean Alemi, MD. It also means your skin looks its best. “They can aid cell turnover and collagen production, which can help reduce fine lines and wrinkles,” says double-board-certified dermatologist Lauren Moy, MD.

Faster cell turnover and increased collagen production can result in skin that is firmer, smoother, and more radiant, looking clear, fresh, and everything you want from a beauty product. What’s particularly valuable about growth factor serums is that they tend to be non-irritating, making them suitable for all skin types, even sensitive skin. Unlike harsher, faster-acting actives like exfoliating acids and retinoids, growth factors slowly transform your skin.

With all of these benefits, a growth factor serum might be considered a daily must-have, but before you invest, read on: Not all anti-aging skin care formulas in this category are created equal. Where things get tricky is where the ingredients come from—for example, human growth factor is found in some of these rejuvenating serums. (Some people may find this ingredient compelling, while others may find it disturbing.) With help from our experts, we’re breaking down these active ingredients, what you should look for in an effective product, and some of our favorite formulas to add to your cart.

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Best Overall: SkinMedica TNS Advanced+ Serum

Why we love it: “This is considered the pioneer and gold standard of growth factor serum, and is one of the longest-standing and best-studied serums on the market,” said Dr. Kahn. This formula contains human fibroblast conditioned medium, naturally rich in growth factors and other cellular materials needed for your own growth factors, as well as peptides, microalgae and more marine extracts to leave skin firmer and smoother. This unique treatment is actually two serums in one, housed in a dual-chamber bottle that pumps out a perfectly blended dose. It’s silky smooth, absorbs extremely well, and pairs well with other products (even makeup), making it easy to incorporate into your daily routine.
Growth factor type: Human fibroblast conditioned medium
Main ingredients: Peptides, algae extracts
size: 1 FL oz.

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